An imbalance of the body’s oxygen producing free radicals and its antioxidant cells could be the reason why periodontal disease and chronic kidney disease affect each other, a study led by the University of Birmingham has found.
Previous studies have shown a link between the severe oral inflammation caused by periodontitis and chronic kidney disease (CKD) which demonstrated that those with worse periodontal inflammation have worse kidney function.
Previous research also showed patients with CKD and periodontitis experience a drop in survival rates, similar in magnitude to if they had diabetes instead of periodontal inflammation, suggesting periodontal inflammation may casually affect kidney function.
In this study, led by researchers at the University of Birmingham, over 700 patients with chronic kidney disease were examined using detailed oral and full-body examinations including blood samples. The aim was to test the hypothesis that periodontal inflammation and kidney function affect each other and to establish the underlying mechanism which may facilitate this.
Results showed just a 10% increase in periodontal inflammation reduces kidney function by 3%. In this group of patients, a 3% worsening in kidney function would translate to an increase in the risk of kidney failure over a 5-year period from 32%-34%. Results also showed a 10% reduction in kidney function increases periodontal inflammation by 25%.
In contrast to current beliefs that inflammation is the link between periodontitis and other systemic diseases, researchers found for the first time, that in this group of patients, the effect was caused by a biological process called ‘oxidative stress’ – or, an imbalance between reactive oxygen species and the body’s antioxidant capacity which damages tissues on a cellular level.
Lead author Dr. Praveen Sharma, from the Periodontal Research Group at the University of Birmingham’s School of Dentistry, said, “This is the first paper to quantify the casual effect of periodontitis on kidney function and vice-versa as well as the first to elucidate the pathways involved.”
“It showed even a modest reduction in gum inflammation can benefit renal function. Given the relative ease of achieving a 10% reduction in gum inflammation, through simple measures like correct brushing techniques and cleaning between the teeth, these results are very interesting.”
“We hope that this research paves the way for further studies to see if improvements in kidney function, following periodontal care, translate to longer, healthier life for patients with chronic kidney disease. We would also hope the hypothesis we have identified could be tested in other groups.”